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. 2020 Feb 11;10:2349. doi: 10.1038/s41598-020-59127-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap and clustering of lipids and LEA participants. The heatmap visualizes 201 lipidomic features at fasting state in all LEA participants (N = 38). Lipids are categorized as Glycerolipids, Glycerophospholipids, Sphingolipids or Miscellaneous. The heatmap shows the hierarchical clustering dendrograms of 201 lipidomic features with Steno Diabetes Center in-house annotations and for the participants. The bars on the left side of the heatmap show LEA status, FHA status and the clustering based on SOM. In the LEA sidebar, the darker color reflects LEA status, while lighter color reflects sufficient EA. In the FHA sidebar, the darker color reflects FHA status, while lighter color reflects EUM.