Table 2.

Associations between lipidomic features with Steno Diabetes Center in-house library annotations and clinical biomarkers at fasting state (N = 38).

Outcome	Lipidomic feature	β	SE	P	PFDR	Annotation type	m/z value	Retention time
Cortisol (mmol/l)	LPC(22:5)	81,63	17,83	5,42E-05	0,035	SDC in-house	570.36	3.80
Cortisol (mmol/l)	LPC(18:2)	77,08	18,39	1,71E-04	0,048	SDC in-house	520.34	3.79
Cortisol (mmol/l)	PC(42:6)	77,36	18,35	1,60E-04	0,048	SDC in-house	862.63	7.11
HDL-C (mmol/l)	SM(d38:1)	0,233	0,041	1,56E-06	0,009	SDC in-house	759.64	7.82
HDL-C (mmol/l)	SM(d32:1)	0,200	0,045	9,29E-05	0,041	SDC in-house	675.54	6.35
HDL-C (mmol/l)	PC(O-36:2)	0,200	0,045	9,38E-05	0,041	SDC in-house	772.62	7.58
TC (mmol/l)	SM(d33:1)	0,488	0,111	9,41E-05	0,041	SDC in-house	689.56	6.63
TC (mmol/l)	SM(d18:2/18:1)	0,482	0,112	1,18E-04	0,047	SDC in-house	727.57	6.48
TC (mmol/l)	CE(18:2) + Unknown CE(667.6219)	0,474	0,113	1,62E-04	0,048	SDC in-house	1315.20	9.72

Abbreviations: β - effect sizes from linear regression models; CE - cholesteryl ester; HDL-C - high-density lipoprotein cholesterol; LPC - lysophosphatidylcholine; m/z - mass-to-charge ratio; PC - phosphatidylcholine; SDC - Steno Diabetes Center; SE - standard error; SM - sphingomyelin; TC - total cholesterol.

P values were calculated using linear regression models. P_FDR values were adjusted using the Benjamini-Hochberg false discovery rate (FDR = 0.05). Annotation types are described in Materials and Methods.