Table 2.

IFNγ production patterns in ELISPOTs of 171 samples from 43 patients in the exploratory analysis, comparing patterns at enrolment, with those following optimization.

Interpretation based on pattern of anti-donor responsiveness	Number of samples (%)
	Enrolment (n = 43)*	Post-optimization (n = 128)	Total (n = 171)
No response	26 (60.5%)	89 (69.5%)	115 (67.3%)
CD25+ or CD19+ regulated	8 (18.6%)	29 (22.6%)	37 (21.6%)
B-dependent—no regulation	8 (18.6%)	8 (6.3%)	16 (9.3%)
Not viable/Not interpretable	1 (2.39%)	2 (1.6%)	3 (1.8%)

^*This analysis is of samples from 43 of the 47 recruits included in the exploratory analysis, who had enrolment PBMC collected.

Comparing enrolment vs. post-optimization patterns in a Fisher 2 × 3 exact probability test [(No response + regulated response) vs. B-dependent responses vs. non-viable], p = 0.04.

Refer to Supplementary Tables 7, 8 to see the individual ELISPOTs from all 43 patients included in this table.