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Propranolol inhibits dextrorphan formation velocity by liver microsomes from TG and WT mice in a time‐ and concentration‐dependent manner. In (a) and (b), propranolol (0‐1 µM) inhibition of dextrorphan formation velocity by pooled TG and WT mouse liver microsomes (0.1 mg·ml−1) was preincubation time and dose‐dependent. In (c) and (d), the rate of inactivation of CYP2D (Kobs) by each propranolol concentration was plotted to determine kinactivation and KI
