Figure 7.
Serum haloperidol, serum haloperidol AUC60–180, and acute haloperidol‐induced catalepsy are increased (within animals) in TG and WT mice after 24 hr i.p. propranolol pretreatment. After 24 hr i.p. pretreatment with either saline or propranolol, all mice were given a s.c. injection of 0.1 mg·kg−1 of haloperidol, and serum haloperidol levels were assessed at 60 and 180 min after the haloperidol injection (a and b), and serum haloperidol AUC from 60 to 180 min was derived (c and d). Catalepsy was tested at 120 min after haloperidol injection (e and f). Data are expressed as mean (with SEM) values of each individual animal normalized to the saline pretreated group, within the same mouse line. Pretreatments were given 2 weeks apart. *P < .05, significantly different from saline pretreated group; two‐tailed, paired t test on the raw data