Fig. 3.

Individual versus collective-cell vessel co-option. GBMs with a prevalent collective-cell vessel co-option are probably mainly composed of astrocyte-like GBM cells. These tumors show disruption astrocyte-vascular coupling and BBB, with a consequent blood vessel leakage and abnormal vasculature (large lumen and tortuous architecture), inflammation caused by vessel leakage and an increase of angiogenic stimuli. While GBMs with more individual-cell vessel co-option are composed of a prevalence of OPC-like GBM cells. These tumors are characterized by a much more subtle infiltration of the surrounding tissue, with no inflammation and vascular leakage