Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 21;9(4):1307–1320. doi: 10.1002/cam4.2738

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Cell migration is inhibited upon Snail knock‐down and enhanced by biguanide treatment. (A) Protein expression levels of mesenchymal markers (Snail, Vimentin, N‐cadherin and Twist) and E‐cadherin in A2780CR, A2780CR/shVector and A2780CR/shSnail 10‐2 ovarian cancer cells. A2780CR/shVector, A2780CR/shSnail 10‐2 ovarian cancer cells were treated for 24 hours and wound healing assay was performed to evaluate cell migration: (B) phenformin, phenformin‐olaparib 0.1 µmol/L and phenformin‐olaparib 0.5 µmol/L. (C) Metformin, metformin‐olaparib 0.1 µg, and metformin‐olaparib 0.5 µmol/L. Data represent the mean ± SEM for triplicate of three independent experiments, statistical significance is represented by *(P < 0.05) and **(P < 0.01).