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. 2019 Dec 21;9(4):1307–1320. doi: 10.1002/cam4.2738

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© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cell survival is inhibited upon Snail knock‐down and enhanced by biguanide treatment. A2780CR/shVector, A2780CR/shSnail 10‐2 ovarian cancer cells were treated for 7 days with biguanides alone or in combination with olaparib and survival was determined using clonogenic assays. (A) Phenformin, phenformin‐olaparib 0.1 µmol/L and phenformin‐olaparib 0.5 µmol/L. (B) Metformin, metformin‐olaparib 0.1 µmol/L, and metformin‐olaparib 0.5 µmol/L. The evaluation of combination index for A2780CR/shVector (C) or A2780CR/shSnail 10‐2, (D) treated with phenformin or metformin and olaparib was calculated where CI < 1 indicates synergy between the two drugs and CI > 1 indicates an additive effect. Data represent the mean ± SEM for triplicate of three independent experiments, statistical significance is represented by *(P < .05) and **(P < .01)