Table 2.
All grade 1‐2 treatment‐related toxicities, and all grade 3‐4 toxicities regardless of attribution
| Event | Treatment‐related grade 1‐2 | Grade 3‐4 (any attribution) | ||
|---|---|---|---|---|
| No of patients | % | No of patients | % | |
| Cardio‐renal | ||||
| Hyponatremia | 1 | 6 | ||
| Constitutional | ||||
| Fatigue or lethargy | 5 | 29 | ||
| Flu‐like symptoms | 2 | 12 | ||
| Hot flashes | 1 | 6 | ||
| Myalgias | 1 | 6 | ||
| Dermatologic | ||||
| Injection site reactions | 16 | 94 | ||
| Pruritus | 2 | 12 | ||
| Rash | 2 | 12 | ||
| Endocrine | ||||
| Hypothyroidism | 4 | 24 | ||
| Gastrointestinal | ||||
| Anorexia | 1 | 6 | ||
| AST elevation | 1 | 6 | ||
| Hematologic | ||||
| Anemia (hemolytic) | 1 | 6 | ||
| Anemia (non‐hemolytic) | 1 | 6 | ||
| Other | ||||
| Corneal transplant rejection | 1 | 6 | ||
| CPK increased | 1 | 6 | ||
| Hip fracture | 1 | 6 | ||
| Pulmonary | ||||
| Shortness of breath | 1 | 6 | ||
Abbreviation: AST, aspartate aminotransferase; CPK, creatine phosphokinase.