Table 1.
Baseline characteristic of metastatic biliary tract cancer patients at initial diagnosis
| Factors | ICC, n (%) | PHCC, n (%) | GBC, n (%) | DCC, n (%) | AVC, n (%) | P | Total, n (%) |
|---|---|---|---|---|---|---|---|
| Number of patients | 1762 | 1103 | 2580 | 538 | 365 | 6348 | |
| Age, years | |||||||
| ≤59 | 573 (32.5) | 280 (25.4) | 625 (24.2) | 127 (23.6) | 89 (24.4) | <.001 | 1694 (26.7) |
| 60‐69 | 577 (32.7) | 364 (33.0) | 751 (29.1) | 184 (34.2) | 99 (27.1) | 1975 (31.1) | |
| 70‐79 | 417 (23.7) | 287 (26.0) | 688 (26.7) | 133 (24.7) | 103 (28.2) | 1628 (25.6) | |
| ≥80 | 195 (11.1) | 172 (15.6) | 516 (20.0) | 94 (17.5) | 74 (20.3) | 1051 (16.6) | |
| Sex | |||||||
| Male | 924 (52.4) | 537 (48.7) | 791 (30.7) | 276 (51.3) | 200 (54.8) | <.001 | 2728 (43.0) |
| Female | 838 (47.6) | 566 (51.3) | 1789 (69.3) | 262 (48.7) | 165 (45.2) | 3620 (57.0) | |
| Race | |||||||
| White | 1359 (77.1) | 842 (76.3) | 1900 (73.6) | 415 (77.1) | 283 (77.5) | <.001 | 4799 (75.6) |
| Black | 144 (8.2) | 104 (9.4) | 381 (14.8) | 58 (10.8) | 46 (12.6) | 733 (11.5) | |
| Others | 259 (14.7) | 157 (14.2) | 299 (11.6) | 65 (12.1) | 36 (9.9) | 816 (12.9) | |
| Year at diagnosis | |||||||
| 2010‐1013 | 787 (44.7) | 577 (52.3) | 1417 (54.9) | 293 (54.5) | 203 (55.6) | <.001 | 3277 (51.6) |
| 2014‐2016 | 975 (55.3) | 526 (47.7) | 1163 (45.1) | 245 (45.5) | 162 (44.4) | 3071 (48.4) | |
| Marriage | |||||||
| Yes | 1031 (58.5) | 588 (53.1) | 1290 (50.0) | 290 (53.9) | 190 (52.1) | <.001 | 3389 (53.4) |
| No | 731 (41.5) | 515 (46.7) | 1290 (50.0) | 248 (46.1) | 175 (47.9) | 2959 (46.6) | |
| Income | |||||||
| Low | 816 (46.3) | 582 (52.8) | 1327 (51.4) | 289 (53.7) | 187 (51.2) | .001 | 3201 (50.4) |
| High | 946 (53.7) | 521 (47.2) | 1253 (48.6) | 249 (46.3) | 178 (48.8) | 3147 (49.6) | |
| Insurance | |||||||
| Yes | 1699 (96.4) | 1043 (94.6) | 2428 (94.1) | 512 (95.2) | 347 (95.1) | .016 | 6029 (95.0) |
| No | 63 (3.6) | 60 (5.4) | 152 (5.9) | 26 (4.8) | 18 (4.9) | 319 (5.0) | |
| Region | |||||||
| East | 632 (35.9) | 350 (31.7) | 966 (37.4) | 222 (41.3) | 122 (33.4) | <.001 | 2292 (36.1) |
| Pacific Coast | 922 (52.3) | 646 (58.6) | 1265 (49.0) | 241 (44.8) | 200 (54.8) | 3274 (51.6) | |
| Northern Plain | 131 (7.4) | 72 (6.5) | 222 (8.6) | 54 (10.0) | 28 (7.7) | 507 (7.99) | |
| Alaska/Southwest | 77 (4.4) | 35 (3.2) | 127 (4.9) | 21 (3.9) | 15 (4.1) | 275 (4.33) | |
| Residence city | |||||||
| Small | 262 (14.9) | 158 (14.3) | 404 (15.7) | 107 (19.9) | 57 (15.6) | .087 | 988 (15.6) |
| Middle | 391 (22.2) | 257 (23.3) | 527 (20.4) | 113 (21.0) | 73 (20.0) | 1361 (21.4) | |
| Large | 1109 (62.9) | 688 (62.4) | 1649 (63.9) | 318 (59.1) | 235 (64.4) | 3999 (63.0) | |
| Tumor size, mm | |||||||
| ≤30 | 115 (6.5) | 165 (15.0) | 394 (15.3) | 118 (21.9) | 123 (33.7) | <.001 | 915 (14.4) |
| 30‐59 | 213 (12.1) | 129 (11.7) | 439 (17.0) | 59 (11.00 | 61 (16.7) | 901 (14.2) | |
| >60 | 576 (32.7) | 97 (8.8) | 354 (13.7) | 25 (4.6) | 13 (3.6) | 1065 (16.8) | |
| Unknown | 858 (48.7) | 712 (64.5) | 1393 (54.0) | 336 (62.5) | 168 (46.0) | 3467 (54.6) | |
| Differentiation | |||||||
| I‐II | 263 (14.9) | 105 (9.5) | 490 (19.0) | 52 (9.7) | 123 (33.7) | <.001 | 1033 (16.3) |
| III‐IV | 277 (15.7) | 135 (12.2) | 686 (26.6) | 75 (13.9) | 103 (28.2) | 1276 (20.1) | |
| Unknown | 1222 (69.4) | 863 (78.3) | 1404 (54.4) | 411 (76.4) | 139 (38.1) | 4039 (63.6) | |
| T stage | |||||||
| T1‐T2 | 946 (53.7) | 339 (30.7) | 500 (19.4) | 140 (26.0) | 127 (34.8) | <.001 | 2052 (32.3) |
| T3‐T4 | 335 (19.0) | 161 (14.6) | 1340 (51.9) | 183 (34.0) | 140 (38.4) | 2159 (34) | |
| TX | 481 (27.3) | 603 (54.7) | 740 (28.7) | 215 (40.0) | 98 (26.9) | 2137 (33.7) | |
| N stage | |||||||
| N0 | 739 (41.9) | 468 (42.4) | 1073 (41.6) | 272 (50.6) | 176 (48.2) | .003 | 2728 (43.0) |
| N1 | 693 (39.3) | 412 (37.4) | 1034 (40.1) | 175 (32.5) | 134 (36.7) | 2448 (38.6) | |
| Nx | 330 (18.7) | 223 (20.2) | 473 (18.3) | 91 (16.9) | 55 (15.1) | 1172 (18.5) | |
| Metastasis site | |||||||
| Bone only | 109 (6.2) | 24 (2.2) | 39 (1.5) | 12 (2.2) | 4 (1.1) | <.001 | 188 (3.0) |
| Brain only | 2 (0.1) | 1 (0.1) | 3 (0.1) | 1 (0.2) | 3 (0.8) | 10 (0.2) | |
| Liver only | 344 (19.5) | 481 (43.6) | 1281 (49.7) | 248 (46.1) | 200 (54.8) | 2554 (40.2) | |
| Lung only | 159 (9.0) | 51 (4.6) | 79 (3.1) | 31 (5.8) | 33 (9.0) | 353 (5.6) | |
| dLN only | 254 (14.4) | 115 (10.4) | 255 (9.9) | 46 (8.6) | 16 (4.4) | 686 (10.8) | |
| Other | 288 (16.4) | 158 (14.3) | 463 (18.0) | 96 (17.8) | 54 (14.8) | 1059 (16.7) | |
| Multi‐metastasis | 606 (34.4) | 273 (24.8) | 460 (17.8) | 104 (19.3) | 55 (15.1) | 1498 (23.6) | |
| Radiation | |||||||
| Yes | 193 (11.0) | 89 (8.1) | 193 (7.5) | 46 (8.6) | 29 (7.9) | .002 | 550 (8.7) |
| No | 1569 (89.0) | 1014 (91.9) | 2387 (92.5) | 492 (91.4) | 336 (92.1) | 5798 (91.3) | |
| Palliative surgery | |||||||
| Yes | 71 (4.0) | 50 (4.5) | 858 (33.3) | 43 (8.0) | 50 (13.7) | <.001 | 1072 (16.9) |
| No | 1691 (96.0) | 1053 (95.5) | 1722 (66.7) | 495 (92.1) | 315 (86.3) | 5276 (83.1) | |
| Chemotherapy | |||||||
| Yes | 1049 (59.5) | 527 (47.8) | 1283 (49.7) | 261 (48.5) | 212 (58.1) | <.001 | 3332 (52.5) |
| No | 713 (40.5) | 576 (52.2) | 1297 (50.3) | 277 (51.5) | 153 (41.9) | 3016 (47.5) | |
P < .05 is considered statistically significant (bold).
Abbreviation: AVC, Carcinoma of Vater ampulla; dLN, Distant lymph node; DCC, Distal cholangiocarcinoma; GBC, Gallbladder cancer; ICC, Intrahepatic cholangiocarcinoma; PHCC, Perihilar cholangiocarcinoma.