Inclusion criteria |
1. Full-text available; |
2. Written in English; |
3. Articles published in the last 20 years; |
4. Articles containing original data; |
5. Studies must be related to “macrophages” in the tendon tissue; |
6. Achilles related studies; |
7. Macrophages related number or proportion were measured in a quantitative or semi-quantitative format; |
8. The quantification/semi-quantification of macrophages cell numbers had to involve the use of specific cell markers (CD68, CD80, CD86, CD163, and CD206) as defined by the individual studies. |
Exclusion criteria |
1. No control group (control group was defined as either a healthy tendon or a division between different tendinopathy groups); |
2. Patients only with infective or known “inflammatory” tendon disease without subgroup analysis of tendon structural damage; |
3. In vitro studies; |
4. Sampling method described inconsistently; |
5. Staining methods not using specific markers; |
6. Case reports, case series, review articles, letters or chapters; |
7. Not available in English language. |