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. 2020 Jan 31;29:105217. doi: 10.1016/j.dib.2020.105217

Table 1.

A summary of vectors bearing genes for production of model recombinant biotherapeutic molecules used and in Budge et al. [1]. The type of recombinant molecule produced by the vector and number of genes required for expression of these molecules are outlined. The figures in which the vectors have been used and a brief description of the method by which they have been utilized are summarized.

Vector Recombinant Molecule Type No. of Genes Brief Method
cB72.3 IgG4 2 Vector used to generate cells stably expressing cB72.3 molecule using hosts previously engineered to overexpress LMM molecules.
Vector used to transiently produce cB72.3 molecule.
Fc-Fusion Protein Fc fusion protein (FcFP) 1 Vector used to generate cells stably expressing an Fc fusion protein using hosts previously engineered to overexpress LMM molecules.
Vector used to transiently produce an Fc fusion protein.
IL2-F-Control Interleukin 2 fused bispecific antibody 3 plus LMM gene Vectors bearing both IL2-F genes and LMM genes used to transiently co-transfect.
IL2-F-SCD1
IL2-F-SREBF1
IL-2-F Interleukin 2 fused bispecific antibody 3 Vector used to generate cells stably expressing IL2-F molecule using hosts previously engineered to overexpress LMM molecules.
DTE-IgG1 IgG1 2 Vector used to generate cells stably expressing DTE-IgG1 molecule using hosts previously engineered to overexpress LMM molecules.