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. 2019 Nov 2;9(3):349–368. doi: 10.1016/j.jcmgh.2019.10.010

Figure 3.

Figure 3

AXL inhibition reduces liver fibrosis and inflammation in MCD-fed mice. (A) Representative images of liver sections after H&E and Sirius Red staining; bar (200 μm). Sirius Red quantifications using ImageJ software in 6 random sections from each animal are shown below the respective pictures. Student’s t test; *P ≤ .05 vs control mice, #P ≤ .05 vs MCD-fed mice; n = 5–6 independent samples. (B) Collagen determination by hydroxyproline quantification in liver samples (n = 4–5) and (C) mRNA expression level of MCP-1, TNF, α-SMA, MPO, F4/80, and β-actin in liver samples from treated mice. Results are expressed as mean plus standard deviation (n = 4–5). *P ≤ .05 vs control mice; #P ≤ .05 vs MCD-fed mice; Student’s t test. (D, E) Body and liver weight were measured after sacrifice in mice fed for 6 weeks with chow and MCD diet that received vehicle or bemcentinib (BGB324) oral gavages for the last 2 weeks. *P ≤ .05 vs control; n = 4–5. The results shown are representative for 2 independent experiments.