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. 2019 Nov 2;9(3):349–368. doi: 10.1016/j.jcmgh.2019.10.010

Figure 5.

Figure 5

Reduction of profibrotic and proinflammatory gene and protein expression by bemcentinib administration to HFD-fed mice. (A) mRNA expression level of α-SMA, COL1A1, MMP9, TNF, MCP1, CCR2, MPO, and F4/80 were measured in liver samples from animals receiving chow or HFD diet with or without administration of AXL inhibitor bemcentinib.*P ≤ .05, **P ≤ .01, and ***P ≤ .001 between groups; 1-way analysis of variance; n = 5–14. (B, C) Representative images of liver immunohistochemistry of α-SMA and F4/80 expression in mice treated as above. Scale bar = 100 μm.