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. 2019 Nov 2;9(3):349–368. doi: 10.1016/j.jcmgh.2019.10.010

Figure 6.

Figure 6

Increased serum sAXL in diet-induced NASH mice as consequence of ADAMs and AXL upregulation. (A–C) Serum GAS6, sAXL, and MERTK levels were measured in mice fed with chow diet and HFD gavaged with vehicle or bemcentinib.*P ≤ .05, **P ≤ .01, and ***P ≤ .001 between groups; 1-way analysis of variance; n = 5–8. (D) Analysis of AXL inhibition in HFD-fed mice using an mRNA Array containing fibrosis- and inflammation-related genes (n = 6). (E) Expression changes of AXL, ADAM10, and ADAM17 mRNA in HFD-fed mice. Results are expressed as mean plus standard deviation.*P ≤ .05 vs control mice; n = 3. (F) Representative Western blot of ADAM10, ADAM17, and GADPH protein expression in chow- and HFD-fed mice. (G) Levels of sAXL secreted from LX2 cells in the presence or absence of ADAM10 inhibitor (GI254023X), ADAM17 inhibitor (TMI-005), or both. *P ≤ .05 vs untreated cells; #P ≤ .05 vs ADAM10 or ADAM17 inhibitors; n = 4–8.