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. 2019 Nov 2;9(3):349–368. doi: 10.1016/j.jcmgh.2019.10.010

Figure 7.

Figure 7

AXL-deficient mice display partial protection against liver fibrosis and inflammation in HFD-fed mice. (A) Representative images of liver sections after H&E and Sirius Red staining from control and AXL KO mice treated with chow or HFD diet. Scale bar = 200 μm. Sirius Red quantification is shown below the respective pictures. Student’s t test; *P ≤ .05 vs control mice. (B) alanine aminotransferase (ALT) serum levels from treated mice (n = 3–6). (C–E) mRNA expression level of COL1A1, TNF, and CCR2 in liver samples from treated mice (n = 3–6). (F) NAFLD Activation Score, composed by (G) steatosis, (H) lobular inflammation, and (I) hepatocellular ballooning, was evaluated in liver samples from treated mice. One-way analysis of variance; *P ≤ .05 vs HFD-fed mice; n = 3–6. The results shown are representative for 2 independent experiments.