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. 2019 Nov 2;9(3):349–368. doi: 10.1016/j.jcmgh.2019.10.010

Figure 8.

Figure 8

MERTK deficiency increased liver fibrosis and inflammation in HFD-fed mice. (A) Representative images of liver sections after H&E and Sirius Red staining from control and MERTK KO mice treated with chow or HFD diet. Scale bar = 200 μm. Sirius Red quantification is shown below the respective pictures. Student’s t test; *P ≤ .05 vs control mice, #P ≤ .05 vs HFD-fed mice; n = 3–6. (B) Alanine aminotransferase (ALT) serum levels from treated mice (n = 3–6). (C, D) mRNA expression level of TNF and MPO in liver samples from treated mice. *P ≤ .05 vs control mice; #P ≤ .05 vs HFD-fed mice; n = 3–6. (E) NAFLD activation score, composed by (F) steatosis, (G) lobular inflammation, and (H) hepatocellular ballooning, was evaluated in liver samples from treated mice. One-way analysis of variance. *P ≤ .05 vs HFD-fed mice; n = 3–6. The results shown are representative for 2 independent experiments.