Table 1.
Biochemical Data From Control Individuals and NASH Patients
| Steatosis (F0) | Fibrosis (F1–F3) | Cirrhosis (F4) | Control values | |
|---|---|---|---|---|
| Men/women | 9/3 | 10/2 | 8/4 | 7/5 |
| Body mass index, kg/m2 | 36.0 ± 2.2a | 32.6 ± 1.6a | 32.5 ± 1.4a | <25 |
| Age, y | 57.0 ± 3.25 | 60.7 ± 2.0 | 63.5 ± 1.5 | 51.7 ± 10.4 |
| Bilirubin, mg/dL | 0.62 ± 0.06 | 0.74 ± 0.07 | 3.19 ± 1.50a | 0.2–1.0 |
| Albumin, g/L | 44.5 ± 0.6 | 44.1 ± 0.7 | 37.3 ± 1.8b,c | 35–50 |
| Quick, % | 94.9 ± 2.0 | 90.8 ± 2.6 | 73.2 ± 4.0b,c | 70 –100 |
| Creatinine, mg/dL | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.6–1.2 |
| AST, U/L | 49.6 ± 13.1a | 40.6 ± 5.2a | 64.3 ± 9.2a,c | 10–40 |
| ALT, U/L | 80.0 ± 25.6a | 58.0 ± 9.4a | 55.2 ± 8.6a | 10–35 |
| GGT, U/L | 97.3 ± 36.6a | 131.4 ± 34.2a | 168.0 ± 37.1a | 5–40 |
| Platelets (×103/mm3) | 218 ± 20 | 202 ± 15b | 130 ± 23b,c | 125–400 |
| Leukocytes (×103/mm3) | 8.2 ± 0.9 | 6.7 ± 0.4 | 5.6 ± 0.8 | 3.5–11.0 |
Values are mean ± SEM. For the control group, serums from 12 individuals (7 men and 5 women with average age of 51.7 ± 10.4 years) with BMI <23 kg/m2 were used to measure GAS6, sAXL, and sMERTK levels. Reference ranges for each biochemical parameter are provided, as established for normal individuals according to the Hospital Clínic Core Lab (Barcelona, Spain).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; GGT, γ-glutamyltransferase; NASH, nonalcoholic steatohepatitis.
a
Outside the range of control values.
b
P ≤ .05 vs steatosis group (F0).
c
P ≤ .05 vs fibrosis group (F1–F3).