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. 2020 Jan 15;12(1):203–247.

Figure 2.

Figure 2

Fisetin effectively enhances C. elegans lifespan and fertility. A. Phenotypes of various groups of C. elegans. Scale bar: 100 μm. B. Life span curve: the results showed that, compared with the PBS group, the life span of C. elegans was significantly increased in the fisetin group after CTX treatment. C. Frequency of head thrashes in various groups of C. elegans: Compared with PBS, fisetin significantly increased the frequency of head thrashes after CTX treatment. D. Frequency of body bends in various groups of C. elegans: Compared with PBS, fisetin significantly increased the frequency of body bends after CTX treatment. E. Number of pregnant C. elegans in the various groups: compared with PBS, fisetin significantly increased the number of pregnant C. elegans after CTX treatment. F. qPCR for quantitation of mRNA levels of genes related to the IIS signaling pathway. **P<0.01 vs PBS+CTX group, as calculated by t-test. qPCR results showed that, compared with PBS, fisetin significantly increased the mRNA expression of genes associated with the IIS signaling pathway in C. elegans after CTX treatment.