El‐Sayed 2017.
Methods | Parallel arm "randomized clinical study" conducted in Zagazig University Hospital, Egypt Timing: November 2015 to January 2017 |
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Participants | 100 women randomised (50 per group), 95 women analysed (48 in group 1 and 47 in group 2). Mean age: Group 1: 27.5 ± 4.25; Group 2: 28.03 ± 4.32 Inclusion criteria: Infertile women with clomiphene citrate‐resistant PCOS (150 mg/day for 5 days), aged between 25 and 35 years, infertility duration of ≤ 3 years, BMI < 30 kg/m2 luteinising hormone ≥ 10 IU/ml or LH/FSH ratio ≥ 2, Free androgen index ≥ 4, normal semen analysis in the husband, normal oral glucose tolerance test Exclusion criteria: Hyper‐androgenic disorders such as late onset congenital adrenal hyperplasia, hyperprolactinaemia, thyroid diseases, Cushing's syndrome, androgen‐secreting tumours |
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Interventions | Unilateral laparoscopic ovarian surgery on the right side, using thermal dose adjusted according to ovarian volume (n = 50), versus Bilateral laparoscopic ovarian surgery using thermal dose adjusted to ovarian volume on both sides (n = 50) Follow‐up for 6 months |
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Outcomes | Menstrual cycle resumption, ovulation rate, cumulative pregnancy rate | |
Notes | Further information confirming methods requested from authors 2 August 2017 No conflict of interest Clinical trial registration number: not stated |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomisation was done using a computer |
Allocation concealment (selection bias) | Unclear risk | No details in the paper |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | No details in the paper but unlikely to have occurred |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No details in the paper |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Unilateral LOD group: 2 participants excluded; 1 had a tubal disease which was identified during laparoscopy and 1 missed the follow‐up Bilateral LOD group: 3 participants excluded; 1 was excluded due to endometriosis which was diagnosed during laparoscopy, and 2 participants missed follow‐up |
Selective reporting (reporting bias) | Unclear risk | We could not retrieve the original protocol. The outcomes mentioned in the Methods section are presented in the Results section |
Other bias | Low risk | No evidence of other risk of bias |