Fernandez 2015.

Methods	Parallel randomised controlled trial conducted in France Timing: June 2009 to June 2012
Participants	40 of 252 women randomised, as trial stopped early. Mean age in LOD group was 28 ± 3 years and in the metformin + FSH group was 27 ± 3 years Inclusion criteria: Clomiphene‐resistant, polycystic ovaries Exclusion criteria: Other causes of infertility including tubal factors, male factor, > 36 years of age, thyroid dysfunction
Interventions	LOD: Bipolar needle, 10 punctures at 100 to 130 W 8 mm depth and 2 mm diameter. (n = 19), versus Recombinant FSH plus metformin: 3 months treatment by metformin (start dose 500 g up to a max 1500 g a day) followed by 3 hyperstimulation by FSH + insemination Follow‐up for 6 months
Outcomes	Pregnancy, BMI, hormone levels, follicle count, changing strategy during the study follow‐up
Notes	No conflict of interest Clinical trial registration number: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Central randomisation through a website
Allocation concealment (selection bias)	Unclear risk	Centralised randomisation
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Planned to recruit 126 women but only recruited 40 before trial stopped. 4 women failed to consent and 2 women were lost to follow‐up. Not stated which group they were allocated to. States that all women were analysed regardless of the group they were randomised to
Selective reporting (reporting bias)	Unclear risk	We could not retrieve the original protocol. All outcomes prespecified in the paper appear to have been reported
Other bias	Unclear risk	Trial stopped early due to "difficulty in the inclusion criteria with absence of final agreement by team included".