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Gilteritinib activity against activating and TKI resistance-causing FLT3 mutations. (A) Gilteritinib IC50 levels for proliferation of Ba/F3 cells expressing activating FLT3 TKD mutations. Error bars represent standard deviation (SD) of 3 or more independent experiments. (B) Gilteritinib IC50 levels for proliferation of Ba/F3 cells expressing FLT3-ITD TKD mutations previously associated with FLT3-TKI resistance. Error bars represent SD of 3 or more independent experiments.
