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. 2020 Feb;190(2):286–294. doi: 10.1016/j.ajpath.2019.10.006

Figure 1.

Figure 1

Comparative gross pulmonary inflammation during TDM-induced pathology. Lungs from mice given i.v. TDM (25 μg) were assessed after 7 days and compared with control naive mice. A: The lung weight index was calculated to quantify gross pulmonary inflammation. B: Digital analysis of area occupied due to cellularity confirms induction of inflammatory response. Similar data were obtained in repeated experiments. C and D: Histologic examination of lungs at day 7 post-TDM administration reveals acute granulomatous response culminating in high levels of monocytic infiltration, with increased presence of focal macrophages (D), versus non–TDM-treated control mouse lungs (C). Higher magnification reveals foamy vesiculated macrophages aggregating between regions of relatively normal parenchyma. Formalin-fixed lung sections were stained with hematoxylin and eosin. Sections represent data obtained from repeated experiments. Data are expressed as means ± SEM. n = 3 experiments; n = 4 to 6 mice per group, per experiment. *P < 0.05 versus control. Scale bars = 300 μm. Original magnification: ×10 (main image); ×40 (insets).