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. 2020 Feb;190(2):426–441. doi: 10.1016/j.ajpath.2019.10.014

Figure 5.

Figure 5

Alveolar vasculature and epithelial type II (ATII) cells are reduced in Col6a1−/− Lungs. A: Representative images of alveolar vasculature visualized by isolectin B4 staining (red) in wild-type (WT) and Col6a1−/− lung tissue. B and C: Quantification of vasculature by total lectin staining intensity (B) and lectin staining intensity normalized for cell number in WT and Col6a1−/− lungs (C). D: Representative images of ATII cells visualized by surfactant protein C (SFTPC) staining (green) in WT and Col6a1−/− lungs. E and F: Quantification of total SFTPC-positive cells per field (E) and the percentage of SFTPC-positive cells in WT and Col6a1−/− lungs (F). n = 6 WT lungs (C and F); n = 7 Col6a1−/− lungs (C and F). *P < 0.05, **P < 0.01, and ***P < 0.001 versus WT. Scale bar = 100 μm (A and B).