Table 1.

Top 10 Most Dysregulated IPA Pathways in Col6a1^−/− Lung Tissue by Z-Score

IPA pathway	Z-score	−Log P value
GP6 signaling pathway	7.66	−4.24
Integrin signaling	3.43	−3.5
NF-κB activation by viruses	4.94	−3.46
NF-κB signaling	3.39	−3.21
Tec kinase signaling	1.47	−3.16
Paxillin signaling	4.44	−3
Nitric oxide signaling in the cardiovascular system	2.14	−3
HGF signaling	4.35	−2.89
IL-8 signaling	1.78	−2.89
Leukocyte extravasation signaling	2.71	−2.84

GP6, glycoprotein VI; HGF, hepatocyte growth factor; IPA, Ingenuity Pathway Analysis; Tec, tyrosine protein kinase Tec.