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. 2019 Dec;189(12):2459–2468. doi: 10.1016/j.ajpath.2019.08.013

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© 2019 American Society for Investigative Pathology. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Supplemental Figure S2 — A progesterone receptor (PR)-negative mouse responded to medroxyprogesterone acetate (MPA). A: Cervical sections from HPVtg/Pgr^–/– mice treated with MPA were stained with hematoxylin and eosin (H&E). Note that one mouse does not have any cervical neoplasia (left panel), but the other mouse (n = 16) has CIN and cervical cancer (right panel) (Table 3). B: Cervical sections shown in A were stained for PR (green). Nuclei were counterstained with Hoechst 33258 and pseudocolored red. Dashed lines demarcate the border between the epithelium (ep) and stroma (st). A cervical section from the HPVtg/Pgr^+/– genotype was used as a positive control. Scale bars = 50 μm.