Table 3.
Summary of Worst Diseases of the Cervix in Pgr-Deficient Mice
| Genotype | Treatment group | Group size, n | No disease, n | Dysplasia only, n |
Cancer and dysplasia, n | Cancer incidence, % | ||
|---|---|---|---|---|---|---|---|---|
| CIN1 | CIN2 | CIN3 | ||||||
| HPVtg/Pgr+/− | Control | 6 | 0 | 1 | 4 | 1 | 0 | 0 |
| MPA | 15 | 6 | 6 | 3 | 0 | 0 | 0 | |
| HPVtg/Pgr−/− | Control | 4 | 0 | 2 | 2 | 0 | 0 | 0 |
| MPA | 17 | 1 | 4 | 3 | 1 | 8 | 47.1∗ | |
For Wilcoxon rank sum test, each lesion was given following arbitrary score: no disease = 1; CIN1 = 2; CIN2 = 3; CIN3 = 4; and cancer = 5.
CIN, cervical intraepithelial neoplasia; MPA, medroxyprogesterone acetate.
∗
P < 0.01 versus the other groups (two-sided Fisher exact test).