Table 2.
Baseline patient characteristics.
| Characteristic | Phase 1 (n=10) | Phase 2 (n=10) |
|---|---|---|
| Median age, years (range) | 26 (16–89) | 38 (24–61) |
| Female, n (%) | 2 (20) | 4 (40) |
|
| ||
| Sarcoma subtype, n | ||
| Alveolar soft part sarcoma | 1 | |
| Ewing sarcoma | 1 | |
| Leiomyosarcoma | 2 | |
| Liposarcoma | 3 | |
| MPNST | 3 | 10 |
| NF1 associated, n (%) | 3 (100) | 5 (50) |
| Sporadic, n (%) | 0 (0) | 5 (50) |
|
| ||
| Tumor location at diagnosis, n | ||
| Abdomen | 1 | 1 |
| Extremity | 1 | 4 |
| Head | 1 | 0 |
| Lung | 0 | 1 |
| Mediastinum | 1 | 0 |
| Peritoneum | 1 | 0 |
| Skin | 1 | 0 |
| Spine | 1 | 2 |
| Other | 3 | 2 |
|
| ||
| Primary tumor resected, n (%) | 8 (80) | 4 (40) |
| If yes, margins | ||
| R0: microscopic negative | 1 (12.5) | 2 (50) |
| R1: microscopic positive | 1 (12.5) | 0 (0) |
| R2: gross residual disease | 1 (12.5) | 0 (0) |
| Unknown | 5 (62.5) | 2 (50) |
|
| ||
| History of metastatic disease, n (%) | 9 (90) | 9 (90) |
| Prior chemotherapy regimen, n (%) | 10 (100) | 8 (80) |
| Prior radiation, n (%) | 7 (70) | 6 (60) |
| Prior surgery, n (%) | 10 (100) | 9 (90) |