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. 2020 Feb 3;19:100216. doi: 10.1016/j.jcte.2020.100216

Table 3.

Actions of selected Leukotrienes and other precursors involved in cell signaling.

Molecule Molecular Formula Action
LTA4 graphic file with name fx8.gif Precursor to mediators of inflammation (e.g., smooth muscle contraction; leukocyte recruitment)
LTB4 graphic file with name fx9.gif Activates lipid metabolism, leukocyte recruitment, catabolized by PPARα, inhibition of apoptosis
LTE4 graphic file with name fx10.gif Major product of PMN leukocytes and lymphocytes (murine)
5(S)-HETE graphic file with name fx11.gif Leukotriene precursor, regulates LDL oxidation in monocytes and Mφ’s
12(S)-HETE graphic file with name fx12.gif Activates lipid oxidation (stimulate oxLDL accumulation), leukocyte recruitment & proliferation, regulates monocyte-endothelial cell adhesion interactions
15(S)-HETE graphic file with name fx13.gif Activates lipid oxidation (stimulate oxLDL accumulation), leukocyte recruitment and differentiation, PPAR-γ-specific activation, regulates monocyte-endothelial cell adhesion interactions, activate LDL oxidation in monocytes & Mφ’s, Mφ cholesterol efflux regulatory factor