Table 4.
Pharmacokinetic parameters of crocetin plus derivatives that come from the metabolism of crocin isomers.
| Parameters | Treatment groups | |
|---|---|---|
| affron® 56 mg | affron® 84 mg | |
| T max (min) | 60 | 90 |
| C max (μg/ml) | 0.26 ± 0.12 | 0.39 ± 0.10 |
| Total AUC(0-3h) (μg·h/ml) | 21.07 | 26.15 |
| T 1/2 (h) | 0.85 ± 0.04 | |
| CL (L/h) | 2.70 ± 0.14 | |
| Vd (L) | 3.19 ± 0.00 | |
Total AUC is calculated on the crocetin concentration change from baseline data. ke, T1/2, CL, and Vd are represented as the mean ± SD. Tmax = time to maximum concentration; Cmax = maximum concentration; AUC = area under the curve; T1/2 = half-life time; CL = clearance; Vd = distribution volume.