Table 3.
Methylomes- and transcriptome-associated genes involved in metabolism biosynthesis.
| GeneID | Synonym | Methylation Difference Level (%) | Methylation p-Value | Expression Foldchange | Expression p-Value | Description |
|---|---|---|---|---|---|---|
| N-glycan biosynthesis | ||||||
| LOC101745965 | FucT6 | 15.19663 | 2.85 × 10−25 | 4.233024 | 8.12 × 10−23 | alpha-(1,6)-fucosyltransferase-like [Bombyx mori (domestic silkworm)] |
| LOC101739008 | ALG9 | 17.21088 | 1.25 × 10−25 | 2.306166 | 6.43 × 10−28 | alpha-1,2-mannosyltransferase ALG9 [Bombyx mori (domestic silkworm)] |
| LOC101742247 | Stt3b | 22.27647 | 2.30 × 10−10 | 2.125494 | 3.94 × 10−28 | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Bombyx mori (domestic silkworm)] |
| LOC101744335 | alpha-Man-Ia | 12.0725 | 3.80 × 10−7 | 2.024585 | 1.34 × 10−17 | mannosyl-oligosaccharide alpha-1,2-mannosidase IA [Bombyx mori (domestic silkworm)] |
| LOC101742043 | GmII | 10.32376 | 5.80 × 10−16 | 2.1135 | 2.50 × 10−65 | alpha-mannosidase 2 [Bombyx mori (domestic silkworm)] |
| Glycosaminoglycan biosynthesis—heparan sulfate/heparin | ||||||
| LOC101741346 | EXT2 | 22.1426 | 1.38 × 10−16 | 2.396993 | 7.06 × 10−6 | exostosin-2 [Bombyx mori (domestic silkworm)] |
| LOC101736578 | Hs2st | 21.04841 | 3.40 × 10−15 | 2.298892 | 2.05 × 10−14 | heparin sulfate O-sulfotransferase [Bombyx mori (domestic silkworm)] |
| LOC101737390 | HS6ST2 | 21.02652 | 1.21 × 10−8 | 3.199666 | 4.66 × 10−7 | heparan-sulfate 6-O-sulfotransferase 2 [Bombyx mori (domestic silkworm)] |
| Glutathione metabolism | ||||||
| LOC101745413 | Oplah | 14.92435 | 2.49 × 10−6 | 2.405576 | 3.76 × 10−14 | 5-oxoprolinase [Bombyx mori (domestic silkworm)] |
| LOC101742094 | Srm | 10.35505 | 1.84 × 10−5 | 2.181386 | 3.31 × 10−11 | spermidine synthase [Bombyx mori (domestic silkworm)] |
| LOC692521 | GSTd2 | 11.33547 | 5.47 × 10−5 | 0.426264 | 1.12 × 10−13 | glutathione S-transferase delta 2[Bombyx mori (domestic silkworm)] |
| LOC100862776 | Ggt1 | 12.9659 | 2.17 × 10−7 | 0.149641 | 9.93 × 10−42 | gamma-glutamyl transpeptidase [Bombyx mori (domestic silkworm)] |
| Regulation of lipolysis in adipocytes | ||||||
| LOC101737606 | Ac76E | 10.18663 | 5.91 × 10−5 | 7.139607 | 1.27 × 10−6 | adenylate cyclase type 2 [Bombyx mori (domestic silkworm)] |
| LOC101745072 | irs1-b | 23.61161 | 1.20 × 10−12 | 2.851851 | 2.82 × 10−20 | insulin receptor substrate 1-B [Bombyx mori (domestic silkworm)] |
| LOC100158253 | Pi3k60 | 20.1611 | 8.42 × 10−13 | 2.09716 | 7.71 × 10−44 | phosphatidylinositol 3-kinase 60 [Bombyx mori (domestic silkworm)] |
| Biosynthesis of amino acids | ||||||
| LOC101740956 | ACO1 | 25.61842 | 7.63 × 10−8 | 2.171117 | 6.59 × 10−24 | cytoplasmic aconitate hydratase [Bombyx mori (domestic silkworm)] |
| LOC101740405 | Gs2 | 17.49432 | 3.22 × 10−12 | 0.438415 | 4.33 × 10−29 | glutamine synthetase 2 cytoplasmic [Bombyx mori (domestic silkworm)] |
| LOC101743550 | Ald | 24.49332 | 1.70 × 10−14 | 0.436375 | 5.81 × 10−37 | fructose-bisphosphate aldolase [Bombyx mori (domestic silkworm)] |
| LOC101738188 | argF | 20.62089 | 5.46 × 10−9 | 0.230464 | 1.88 × 10−79 | ornithine carbamoyltransferase-like [Bombyx mori (domestic silkworm)] |
| LOC101738186 | ACO2 | 17.0617 | 6.27 × 10−14 | 0.415694 | 0 | probable aconitate hydratase, mitochondrial [Bombyx mori (domestic silkworm)] |
| Glyoxylate and dicarboxylate metabolism | ||||||
| LOC101740956 | ACO1 | 25.61842 | 7.63 × 10−8 | 2.171117 | 6.59 × 10−24 | cytoplasmic aconitate hydratase [Bombyx mori (domestic silkworm)] |
| LOC101740405 | Gs2 | 17.49432 | 3.22 × 10−12 | 0.438415 | 4.33 × 10−29 | glutamine synthetase 2 cytoplasmic [Bombyx mori (domestic silkworm)] |
| LOC101738186 | ACO2 | 17.0617 | 6.27 × 10−14 | 0.415694 | 0 | probable aconitate hydratase, mitochondrial [Bombyx mori (domestic silkworm)] |