Table 5.
Methylomes- and transcriptome-associated genes involved in cell cycle and apoptosis.
| GeneID | Synonym | Methylation Difference Level (%) | Methylation p-Value | Expression Foldchange | Expression p-Value | Description |
|---|---|---|---|---|---|---|
| G1/S transition of mitotic cell cycle | ||||||
| LOC101746803 | Phf8 | 22.76216 | 1.34 × 10−9 | 4.539773 | 9.05 × 10−12 | histone lysine demethylase PHF8 [Bombyx mori (domestic silkworm)] |
| LOC 100216493 | Cyce | 16.97983 | 6.34 × 10−6 | 2.868805 | 1.35 × 10−97 | cyclin E [Bombyx mori (domestic silkworm)] |
| LOC101741790 | SKP2 | 26.22085 | 0.001772 | 2.090556 | 9.75 × 10−24 | S-phase kinase-associated protein 2 [Bombyx mori (domestic silkworm)] |
| LOC101738704 | ACVR1 | 13.23511 | 1.51 × 10−5 | 2.028722 | 5.10 × 10−59 | activin receptor type-1 [Bombyx mori (domestic silkworm)] |
| Regulation of apoptotic process | ||||||
| LOC101742044 | CG14226 | 10.69776 | 1.84 × 10−11 | 5.6281 | 4.06 × 10−93 | cytokine receptor [Bombyx mori (domestic silkworm)] |
| LOC101739208 | G2e3 | 16.07484 | 2.73 × 10−14 | 2.619197 | 4.72 × 10−51 | G2/M phase-specific E3 ubiquitin-protein ligase [Bombyx mori (domestic silkworm)] |
| LOC101745221 | DLG5 | 11.60066 | 1.46 × 10−06 | 2.141483 | 6.91 × 10−51 | disks large homolog 5 [Bombyx mori (domestic silkworm)] |
| LOC101741790 | SKP2 | 26.22085 | 0.001772 | 2.090556 | 9.75 × 10−24 | S-phase kinase-associated protein 2 [Bombyx mori (domestic silkworm)] |
| LOC101740336 | Sh3kbp1 | 22.78633 | 0.001078 | 2.027284 | 2.31 × 10−45 | CD2-associated protein [Bombyx mori (domestic silkworm)] |
| LOC101738660 | Ppid | 21.54647 | 3.27 × 10−19 | 0.480788 | 6.92 × 10−53 | peptidyl-prolyl cis-trans isomerase D [Bombyx mori (domestic silkworm)] |
| Signaling pathways regulating pluripotency of stem cells | ||||||
| LOC101742798 | Mad | 12.83938 | 0.001686 | 4.322594 | 2.95 × 10−21 | protein mothers against dpp [Bombyx mori (domestic silkworm)] |
| LOC101744534 | BMPR2 | 23.0032 | 1.24 × 10−6 | 4.090361 | 2.39 × 10−30 | probable serine/threonine-protein kinase DDB_G0278901 [Bombyx mori (domestic silkworm)] |
| LOC101740154 | RIF1 | 12.9223 | 2.47 × 10−9 | 2.924023 | 4.05 × 10−19 | telomere-associated protein RIF1 [Bombyx mori (domestic silkworm)] |
| LOC100158253 | Pi3k60 | 20.1611 | 8.42 × 10−13 | 2.09716 | 7.71 × 10−44 | phosphatidylinositol 3-kinase 60 [Bombyx mori (domestic silkworm)] |
| LOC101735864 | KIAA0445 | 15.4856 | 8.89 × 10−7 | 2.064435 | 2.90 × 10−47 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Bombyx mori (domestic silkworm)] |
| LOC101738704 | ACVR1 | 13.23511 | 1.51 × 10−5 | 2.028722 | 5.10 × 10−59 | activin receptor type-1 [Bombyx mori (domestic silkworm)] |