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. 2020 Jan 8;21(2):401. doi: 10.3390/ijms21020401
upregulation
downregulation
5-FU 5-fluorouracil
ABC ATP-binding cassette transporter proteins
ABCB1, ABCG1 isoforms of ATP-binding cassette transporter proteins
ARE antioxidant response element
ABT-263 small molecule that inhibits Bcl-2; 4-(4-{[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl}c-1-piperazinyl)-N-[(4-{[(2R)-4-(4-morpholinyl)-1-(phenylsulfanyl)-2-butanyl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
ABT-737 small molecule that inhibits Bcl-2; 4-{4-[(4′-Chloro-2-biphenylyl)methyl]-1-piperazinyl}-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)-2-butanyl]amino}-3-nitrophenyl)sulfonyl]benzamide
AKT protein kinase B
ALDH aldehyde dehydrogenase
ALP autophagy lysosomes systems
AMPK AMP-activated protein kinase
APAF1 apoptotic protease activating factor 1
APR-246 drug that binds to p53 (restoring p53 function) and depletes glutathione; PRIMA-1, 2-hydroxymethyl-2-methoxymethyl-aza-bicyclo[2.2.2]octan-3-one
AR androgen receptor
ATR serine/threonine protein kinase
Axl, Tyro3 receptors for tyrosine kinase
BASE base excision repair
Bax Bcl-2-associated X protein/Bcl-2-like protein 4
Bcl-2 B cell lymphoma 2 protein
Bcl-XL B cell lymphoma extra-large protein
BCRA1, 2 breast cancer susceptible genes
BCRP breast cancer resistant protein
BER base excision repair
BH Bcl-2 homology domain
BIM Bcl-2 like protein 11
BNDQ quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles
BPIS bound polyphenols of inner shell from foxtail millet bran
BRAF serine/threonine-protein kinase B-Raf
C catechin
CAB carboplatin
CAPE caffeic acid phenethyl ester
CAR constitutive androstane receptor
caspase-3, 8, 9 cysteine aspartic proteases-3, 8, 9
CBZ cabazitaxel
CD44, 24, 133 cluster of differentiation 44, 24, 133
CDF difluorinated curcumin
CDK 2,4,6 cyclin-dependent kinases 2,4,6
CDPP cisplatin
CEA carcioembryonic antigen
cFLIP regulator of caspase-8 activation; cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
CgA chromogranin
Chk1/2 Check point kinase 1/2
cIAP-1,2 cellular inhibitor of apoptosis protein 1,2
COMT catechol-O-methyl transferase
COX-2 ciclo-oxygenase 2
CPT11 irinotecan
CREB-1 element binding protein-1
CRPC castration-resistant prostate cancer
CSC cancer stem cells
CXCR4 CXC chemokine receptor type 4
CYP1A1, CYP1B1, CYP19A1, CYP17A1 isoforms of cytochrome 450
CYP3A4 cytochrome P450 3A4
DDR DNA damage response
DIABLO direct IAP-binding protein with Low pI
DMBA 7,12-dimethylbenz[a] anthracene
DNA deoxyribonucleic acid
DOC docetaxel
DOX doxorubicin (adriamycin)
DPPT deoxypodophyllotoxin
DR4/5 pro-apoptotic death receptors
EC epicatechin
EGC epigallocatechin
EGCG epigallocatechingallate
EGF epidermal growth factor
EGFR epithelial growth factor receptor
EGFR(T790M) epithelial growth factor receptor with a mutation that replace threonine by methionine at position 790
EGR-1 early growth response protein 1
EMT epithelial-mesenchymal transition
ENL enterolactone
ER estrogen receptors
ERα/ERβ estrogen receptor alpha/estrogen receptor beta
ERK 1,2 extracellular-signal regulated kinase
ETS2 proto-oncogene 2, transcription factor (v-ets, Avian Erythroblastosis Virus E26 Oncogene Homolog 2)
EZH2 enhancer of zeste homolog 2 (histone methyltransferase)
FASN fatty acid synthase
FBAP5 fatty acid-binding protein 5
FGF fibroblast growth factor
FOLFOX 5-fluorouracil, oxaliplatin, folinic acid
GF gefitinib
GRP78 glucose regulated protein
GSH reduced glutathione
GSK3 glycogen synthase kinase 3
GST glutathione-S transferase
GPX glutathione peroxidase
GTE green tea extract
HER-2, 3 human epidermal growth factor 2, 3
Her2/neu receptor tyrosine-proteinkinase erbB-2
HGFR/MET hepatocyte growth factor receptor
HIF-1α hypoxia-inducible factor 1 alpha
hMLH1 mismatch repair gene of human mutL homolog 1
HNK honokiol
HO-1 hemeoxygenase 1
HR homologous recombination
HRas transforming protein p21
IAP inhibitors of apoptosis proteins
ICAM-1 intercellular adhesion molecule 1
IGF-1R insulin growth factor receptor
IL-6, 8, 17, 18 interleukin-6, 8, 17, 18
i.p. intraperitoneal administration
i.v intravenous administration
JNK c-Jun N-terminal kinase
Keap 1 kelch-like ECH-associated protein 1
KRAS gene identified in Kirsten rat sarcoma
MAPK mitogen activated protein kinase
MDM2 mouse double minute 2 homolog
MDR multidrug resistance
Meriva turmeric/phospholipid formulation
MET tyrosine-proteinkinase
MLH1,2 human mutL homolog 1,2
MMP mitochondrial membrane potential
MMP-2,9 metalloproteinases 2,9
MMR mismatch repair
MRP1/2 multidrug resistance associated protein 1/2
mRNA messenger RNA
miRNA microRNA
miR-16, 17, 21, 200c, 17-5p, 892c microRNA-16, 17, 21, 200c, 17-5p, 892c
MSH 1/2 DNA mismatch repair protein 1/2
mTOR mammalian target of rapamycin
NAD(P)H reduced nicotinamide adenine dinucleotide phosphate
NER nucleotide excision repair
NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
NGF nerve growth factor
NHEJ non-homologous end-joining
NOX NADPH oxidases
NPs nanoparticles
Nrf2 erythroid 2-related factor 2
NSCLC non-small cell lung cancer
NSE neurospecific enolase
OX oxaliplatin
p53 tumor suppressor protein
P-gp (MDR1) P-glycoprotein (multidrug resistance protein 1)
PI3K/AKT phosphoinositide 3-kinase/protein kinase B
PKC proteinkinase C
p.o. oral administration
PPARβ/δ peroxisome proliferator-activated receptor β/δ
PPT podophyllotoxin
PS phospho-sulindac
PSA prostate serum antigen
PTEN phosphatase and tensin homolog
PTX paclitaxel
PXR pregnane X receptor
RARs retinoic acid receptors
RES resveratrol
ROS reactive oxygen species
SCC squamous cell carcinoma
SChA schizandrin A
SCLC small cell lung cancer
SECO secoisolariciresinol
Smac second mitochondria-derived activator of caspase
SOD superoxide-dismutase
Src proto-oncogene tyrosine-protein kinase
SRT501 small molecule, a form of resveratrol designed to target sirtuin 1 protein
STAT3 signal transducer and activator of transcription 3
T-box 3 T-box transcription factor 3
Tf-PEG-CUR transferrin-poly(ethylene glycol)-curcumin
TGF-β transforming growth factor
TKI tyrosine kinase inhibitors
TME tumor microenvironment
TP53 gene coding tumor suppressor protein p53
TRAIL TNF-related apoptosis-inducing ligand
UGT uridine diphospho-glucuronosyltransferase
VCR vincristine
VEGF vascular endothelial growth factor
VEGFR2 vascular endothelial growth factor receptor 2
Wnt/β-catenin wingless-type MMTV integration site family member (MMTV, mouse mammary tumor virus)/beta-catenin signaling pathway
xCT glutamate cysteine antiporter
XIAP X-linked inhibitor of apoptosis protein
YB-1 Y-box binding protein-1