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Calcium-induced calcium release mechanism (CICR) schematized with T-tubule and sarcomere structures. Ca2+ influx via the L-type calcium channels is able to cause a release of the SR Ca2+ store via the Ca2+-sensitive ryanodine receptors (RYR2). In hiPSC-CMs the Ca2+ entry is mainly the extracellular one and calcium handling kinetics are slower (yellow in the inset) compared to adult CMs (green).
