Figure 2.

The relationship between changes of glucose-induced I_sc (ΔI_sc) and changes of glucose-induced net ²²Na⁺ fluxes (ΔJ^Na _Net) in wild-type mice: Glucose-induced ΔI_sc and net Na⁺ flux (J^Na_Net) were calculated from the data of Figure 1 (short-circuit conditions) and Figure 3 (open-circuit conditions) and replotted. ΔI_sc was determined by subtracting baseline values from those obtained after addition of glucose. Mean values for the last two periods after addition of glucose are taken as the change in I_sc and J^Na. Net Na⁺ flux (J^Na_Net) was calculated using adjacent tissues by subtraction (J^Na_MS − J^Na_SM = J^Na_Net). The lines were fitted by least-squares analysis. r² = 0.623 and 0.006 for the short-circuit (closed circles) and open-circuit (open circles) conditions, respectively.