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. 2020 Jan 19;21(2):666. doi: 10.3390/ijms21020666

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The lack of matrilin-4 leads to age-associated, spontaneous osteoarthritis of the knee joint. (A) HE-stained Matn4^−/− knee joint (original magnification × 10) at 24 months of age exhibited severe osteoarthritis-like phenotype and (B) a significantly higher articular cartilage degeneration score compared to wild type (*** p < 0.001). (C) Immunohistochemistry demonstrates upregulated expression of MATN2 and MATN3 in MATN4-deficient articular cartilage. Original magnifications: ×10 for overview pictures and ×20 for inserts.