A: A 19-month-old boy with group D retinoblastoma with cloud vitreous seeds (case 3); B: Following 3 cycles of IAC (carboplatin, 40 mg; topotecan, 1 mg; melphalan, 4 mg) and 6 injections of IVM (30 µg), complete regression of the retinal tumor and vitreous seeds; C: A 4-year-old boy with group D retinoblastoma with cloud vitreous seeds (case 16); D: Following 3 cycles of IAC (carboplatin, 50 mg; topotecan, 1 mg; melphalan, 5 mg) and 14 injections of IVM (30 µg), complete regression of the retinal tumor and vitreous seeds.