Figure 1.

Reduced hapten-induced contact hypersensitivity upon transfer of cannabinoid receptor 2 (CB2)-deficient dendritic cells (DCs) into recipient mice. (a) Mice were sensitized (S) by subcutaneous (s.c.) injection of haptenized DCs and challenged (C) with 2,4-dinitro-1-fluorobenzene (DNFB). Ear swelling (M) was measured 48 h after the second challenge. (b) Mean ear swelling 48 h after the second challenge with DNFB (± SEM, n = 5 mice/group) in wild type (WT), Cnr1/2^−/−, Cnr1^−/− and Cnr2^−/− mice sensitized with WT DCs, Cnr1^−/−/Cnr2^−/− DCs (top), Cnr1^−/− DCs (middle) and Cnr2^−/− DCs (bottom). Experiments were repeated two times with similar results. * p < 0.05, ** p < 0.01.