BTLA |
B-and T-lymphocyte attenuator |
CHCA |
α-cyano-4-hydroxycinnamic acid |
CD160 |
cluster of differentiation 160 |
CRD |
cysteine-rich domain |
CSI |
chemical shift index |
CTLA-4 |
cytotoxic T-lymphocyte antigen-4 |
DAPI |
4′,6-diamidino-2-phenylindole dihydrochloride |
DSS |
sodium 2,2-dimethyl-2-silapentane-5-sulfonate |
DTT |
dithiothreitol |
ELISA |
enzyme-linked immunosorbent assay |
Fmoc/tBu |
9-fluorenylmethoxycarbonyl/tert-butyl |
HSQC |
heteronuclear single quantum coherence |
HVEM |
herpes virus entry mediator |
IgSF |
immunoglobulin-like superfamily |
ITIM |
immunoreceptor tyrosine-based inhibitory motif |
LC ESI–IT–TOF MS |
liquid chromatography coupled with electrospray ionization, ion trap, and time-of-flight mass spectroscopy |
LIGHT |
homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes |
LTα |
lymphotoxin α |
mAb |
monoclonal antibody |
MS |
mass spectroscopy |
MALDI-TOF |
matrix-assisted laser desorption ionization, time-of-flight |
MREMD |
multiplexed-replica exchange molecular dynamics |
MD |
molecular dynamics |
NOE |
nuclear Overhauser effect |
NOESY |
nuclear Overhauser effect spectroscopy |
NMR |
nuclear magnetic resonance |
PBS |
phosphate-buffered saline |
PD-1 |
programmed cell death 1 |
PDB |
protein data bank |
PD-L1 |
programmed cell death-ligand 1 |
PBMC |
peripheral blood mononuclear cells |
PPIs |
protein–protein interactions |
RP-HPLC |
reverse-phase high-performance liquid chromatography |
RMSD |
root-mean-square deviation |
SPPS |
solid-phase peptide synthesis |
SHP-1 and 2 |
Src homology-2-containing protein 1 and 2 |
SPR |
surface plasmon resonance |
TFA |
trifluoroacetic acid |
TNFR |
tumor necrosis factor receptor |
TOCSY |
total correlation spectroscopy |
UNRES |
UNited RESidue |
WHAM |
weighted histogram analysis method |