Table 3.
Comparative analysis of P450s that are associated with secondary metabolites biosynthetic gene clusters (BGCs). Types of clusters, most similar known cluster and similarity were obtained by submitting individual P450 clusters to anti-SMASH (antibiotics & Secondary Metabolite Analysis Shell) [65]. Standard abbreviations representing type of clusters as indicated in anti-SMASH [65] were used in the table.
| P450 Names | Type of Clusters | Most Similar Known Cluster | Similarity |
|---|---|---|---|
| CYP213A8 | T3PKS | Xenocyloins | 25% |
| CYP213A5 | bacteriocin | ||
| CYP213A6 | T3PKS | Colicin V | 2% |
| CYP110AH1 | NRPS | Anabaenopeptin NZ 857/nostamide A | 100% |
| CYP213A3 | bacteriocin | ||
| CYP120C2 | T2PKS | Ambiguine | 6% |
| CYP110K6 | NRPS | ||
| CYP120A21 | bacteriocin | ||
| CYP110Q3 | NRPS, T1PKS | Hapalosin | 40% |
| CYP110C17 | terpene | ||
| CYP110C29 | NRPS, T1PKS | Nostophycin | 27% |
| CYP1011G1 | NRPS, T1PKS | Crocacin | 23% |
| CYP110AP1 | terpene | ||
| CYP110AT1 | NRPS, T1PKS | Hapalosin | 40% |
| CYP110Q4 | NRPS, T1PKS | Hapalosin | 40% |
| CYP110C21 | NRPS-like | Anacyclamide | 14% |
| CYP197E3 | NRPS, T1PKS | Cryptophycin | 37% |
| CYP110AG1 | terpene | Hectochlorin | 25% |
| CYP110E29 | terpene, thiopeptide, T1PKS, NRPS | Nostophycin | 27% |
| CYP110E18 | terpene, thiopeptide, T1PKS, NRPS | Nostophycin | 27% |
| CYP110C21 | terpene | ||
| CYP110Q4 | NRPS, T1PKS | Puwainaphycins | 40% |
| CYP110AT1 | NRPS, T1PKS | Puwainaphycins | 40% |
| CYP120A13 | ladderane | ||
| CYP1185A1 | lassopeptide, bacteriocin | ||
| CYP110Q2 | NRPS, T1PKS | Hapalosin | 40% |
| CYP110C14 | terpene | 6,6′-oxybis(2,4-dibromophenol) | 14% |