Table 1.
Summary of 3D structures of glycosyltransferases involved in N-glycan maturation. All these data are deposited in Protein Data Bank.
| Enzyme | CAZy Family | Fold | Mechanism | Ligand | PDB Code | Reference |
|---|---|---|---|---|---|---|
| Rabbit GnT-I | GT13 | GT-A | Inverting | UDP-GlcNAc, Mn2+ | 1FOA | [26] |
| (CH3-Hg derivative) | 1FO8 | |||||
| - | 1FO9 | |||||
| Rabbit GnT-I | UDP-CH2-GlcNAc, Mn2+ | 2AM3 | [27] | |||
| 1 UDP-2F-Glc, Mn2+ | 2AM4 | |||||
| UDP, Mn2+ | 2AM5 | |||||
| UDP-GlcNAc phosphonate, Mn2+ | 2APC | |||||
| Human GnT-II | GT16 | GT-A | Inverting | UDP, Mn2+ | 5VCM | [28] |
| (UO2 derivative) | 5VCR | |||||
| Acceptor (GlcNAcMan3GlcNAc) | 5VCS | |||||
| Human GnT-V | GT18 | GT-B | Inverting | - | 5ZIB | [29] |
| Human GnT-V (Mini-GnT-V) | Acceptor (GlcNAcMan2) | 5ZIC | ||||
| Human FUT8 | GT23 | GT-B | Inverting | - | 2DE0 | [30] |
“-”; Ligand free form, 1 UDP-2F-Glc; UDP-2-deoxy-2-fluoro-glucose.