Figure 1.

The workflow used to analyze the blood plasma samples from subjects involved in this study. Blood plasma samples (A) are collected and transported to the laboratory. In the laboratory, using ultrahigh-resolution mass spectrometry (B), the mass spectrum of blood plasma is obtained (C). The obtained mass spectra after preprocessing (alignment and normalization) (D) are analyzed according to a compound annotation algorithm (E), and the retrieved results are used in the metabolite set enrichment analysis (MSEA) (F).