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. 2020 Jan 15;21(2):568. doi: 10.3390/ijms21020568

Table 2.

Results of metabolite set enrichment analysis.

Metabolite Set p Value 1
♂♀ vs. ♂♀ ♂ vs. ♂ ♀ vs. ♀
Normal vs. Overweight Normal vs. Stage 1 Obesity Normal vs. Stage 2 Obesity Normal vs. Stage 3 Obesity Normal vs. Overweight Normal vs. Stage 1 Obesity Normal vs. Stage 2 Obesity Normal vs. Stage 3 Obesity Normal vs. Overweight Normal vs. Stage 1 Obesity Normal vs. Stage 2 Obesity Normal vs. Stage 3 Obesity
Steroidogenesis 3 × 10−6 2 × 10−5 5 × 10−8 5 × 10−12 0.477 - 0.004 0.002 0.094 6 × 10−7 1 × 10−6 1 × 10−10
Androstenedione metabolism 4 × 10−4 0.013 0.017 0.014 - 0.173 0.113 0.045 0.258 0.011 0.065 6 × 10−4
Androgen and estrogen metabolism 9 × 10−4 0.011 0.011 0.002 - - 0.076 0.023 0.042 0.002 0.004 2 × 10−5
Aspartate metabolism 0.062 0.047 0.047 0.378 0.409 0.244 0.251 0.338 0.426 0.015 0.191 0.198
Urea cycle 0.085 0.041 0.120 0.669 0.352 0.019 0.429 0.261 0.027 0.035 0.294 0.302
Ammonia recycling 0.119 0.154 0.171 0.514 0.381 0.225 0.21 0.3 0.744 0.061 0.633 0.358
Estrone metabolism 0.131 0.449 0.56 0.536 - - 0.711 0.57 0.258 0.426 0.204 0.210
Beta-alanine metabolism 0.144 0.733 0.381 0.353 - 0.237 0.829 0.699 0.765 0.322 0.387 0.674
Malate-aspartate shuttle 0.199 0.158 0.106 0.323 0.138 0.075 0.401 0.295 0.343 0.148 0.135 0.139
Glucose-alanine cycle 0.294 0.276 0.471 0.798 - 0.097 0.487 0.365 0.422 0.553 0.587 0.593
Glycine and serine metabolism 0.364 0.005 0.038 0.130 - 0.379 0.338 0.137 0.219 0.010 0.55 0.191
Cysteine metabolism 0.368 0.515 0.376 0.351 - 0.187 0.375 0.600 - 0.491 0.517 0.836
Retinol metabolism 0.369 0.794 0.662 0.426 - - 0.279 0.73 0.794 0.774 0.219 0.227
Tryptophan metabolism 0.38 0.772 0.662 0.55 0.598 0.384 0.586 0.337 0.228 0.744 0.985 0.778
Glutamate metabolism 0.38 0.034 0.662 0.505 0.523 0.325 0.715 0.826 0.609 0.0617 0.636 0.646
Phenylalanine and tyrosine metabolism 0.415 0.783 0.433 0.645 - 0.0182 0.411 0.248 0.0245 0.177 0.275 0.283
Alanine metabolism 0.419 0.211 0.33 0.877 - 0.384 0.583 0.449 0.512 0.422 0.686 0.692
Lysine degradation 0.461 0.822 0.715 0.692 - 0.212 0.447 0.653 - 0.611 0.873 0.605
Histidine metabolism 0.486 0.585 0.407 0.692 - 0.291 0.363 0.438 0.841 0.379 0.544 0.795
Citric acid cycle 0.505 0.483 0.542 0.734 - - 0.81 0.677 0.744 0.271 0.350 0.641

1 Red font indicates p < 0.01; while green font indicates 0.01 < p < 0.05.