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. 2020 Jan 17;21(2):617. doi: 10.3390/ijms21020617

Figure 1.

Figure 1

Signaling pathways involved in wound-induced hair follicle neogenesis (WIHN). Wnt/β-catenin signaling and downstream Shh signaling in keratinocytes activates WIHN. TNF released from macrophages, FGF9 released from γδ T cells, and double-strand RNA binding to TLR3 in keratinocytes induces WIHN. Wnt//β-catenin and TGFβ/Smad signaling in fibroblasts results in fibrosis. Activation of Shh or suppression of Wnt pathways in fibrosis is sufficient to redirect Wnt-active wound fibroblasts to WIHN.