Table 1.
A global overview of the role of protein phosphatases in the DNA damage response (DDR). The table contains information regarding the functions and targets of different protein phosphatases that are implicated in the regulation of the DNA damage response.
| Function | PPase | Target |
|---|---|---|
| DNA damage checkpoint activation | PP1 | hATM, hH2AX, h53BP1, hRPA, hRAD51, hCHK1 |
| PP2A | hATR, hATM, hDNA–PK, hCHK1, hCHK2, hPLK1, hP53 | |
| PP4 | scMec1 | |
| PP5 | hATM, hATR, hDNA–PK, mP53, mCHK1 | |
| CDC14 | spCds1, hCDH1 | |
| DNA repair | PP1 | hBRCA1 |
| PP2A | hDNA–PK, hRPA, hH2AX, hATM, hCHK2 | |
| PP4 | ScRad53, ScH2A, hRPA, hH2AX | |
| CDC14 | scSpc110, scYen1 | |
| DNA damage checkpoint deactivation | PP1 | xCDC25C, hP53, caRad53, scH2A, ScRad53, spChk1 |
| PP2A | hPLK1 | |
| PP4 | scRad53, scH2A, hH2AX, dH2AX | |
| Wip1 | hP53, hCHK1, hCHK2, hH2AX, mATM |
Sc, Saccharomyces cerevisiae; Sp, Schizosaccharomyces pombe; Ca, Candida albicans; d, Drosophila melanogaster; x, Xenopus laevis; m, mice; h, human.