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Design and efficiencies of Cas9 gRNAs targeting TERT. (A) Top: illustration of gRNAs (sg1 to sg5) targeting TERT. E#: Exon#. Bottom: gRNA sequences. Underlined: PAM. (B) Indel efficiencies of sg1, sg2 and sg3 determined by deepseq in Hela, PANC1 and SUM159 cells. Total deepseq reads for each locus were shown in parentheses.
