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. 2020 Jan 8;21(2):387. doi: 10.3390/ijms21020387

Figure 2.

Figure 2

Neutralizing IL-1β antibody rescues Parvalbumin-positive neurons in the globus pallidus (A) Representative images showing PV+neurons in the GP at seven dpi, scale bar 20 μm. (B) Compared with sham-injured, control-treated animals (Sham CsA) at two dpi, there was no change in the number of PV+ neurons (sham CsA, n = 4; sham IL-1β, n = 3; cFPI CsA, n = 6; cFPI IL-1β, n = 6) (C) At seven dpi, the number of PV+ neurons decreased significantly in the brain-injured, control-treated (cFPI CsA) animals in comparison to the sham CsA group (* p ≤ 0.05). The cFPI-induced loss of PV+ neurons was attenuated by the IL-1β neutralization (sham CsA, n = 4 sham IL-1β, n = 3; cFPI CsA, n = 7; cFPI IL-1β, n = 6; * p ≤ 0.05). (D) At 14 dpi, PV+ neurons loss was still detected in the GP (sham CsA, n = 3; sham IL-1β, n = 3; cFPI CsA, n = 8; cFPI IL-1β, n = 11; * p ≤ 0.05) of the cFPI CsA group compared with the sham CsA group; however, the effect of neutralizing IL-1 β did not reach significance. GP, globus pallidus; cFPI, central fluid percussion injury; dpi, days post-injury; CsA, inactive control antibody against cyclosporin A; IL-1β, interleukin-1 beta; PV, parvalbumin.