Table 3.
Vibriocidal antibody responses by age groups after vaccination with Shanchol™ oral cholera vaccine.
| Baseline |
Day 14 (14 days post first vaccine dose) |
Day 28 (14 days post second vaccine dose) |
||||
|---|---|---|---|---|---|---|
| Boosted Group (n = 59) | Primary Immunized Group (n = 57) | Boosted Group (n = 59) | Primary Immunized Group (n = 57) | Boosted Group (n = 57) | Primary Immunized Group (n = 56) | |
| Adults | GMTa(95% CI) | GMTa(95% CI) | GMTa(95% CI) | GMTa(95% CI) | GMTa(95% CI) | GMTa(95% CI) |
| O1 Inaba | 50.00 (34.43, 72.62) | 40.98 (28.04, 59.91) | 298.22 (227.26, 391.34) | 273.21 (207.22, 360.22) | 194.37 (150.65, 250.77) | 199.93 (154.61, 258.53) |
| O1 Ogawa | 57.57 (39.08, 84.82) | 40.49 (27.30, 60.06) | 268.30 (209.13, 344.20) | 230.44 (178.85, 296.91) | 174.22 (134.84, 225.09) | 160.00 (123.56, 207.19) |
| O139 | 52.41 (36.97, 74.29) | 56.23 (39.42, 80.19) | 154.46 (116.85, 204.17) | 176.35 (132.77, 234.24) | 133.32 (100.76, 176.41) | 164.01 (123.64, 217.55) |
| Older children | (n = 30) | (n = 30) | (n = 30) | (n = 30) | (n = 30) | (n = 28) |
| O1 Inaba | 16.25 (9.58, 27.56) | 17.82 (10.50, 30.23) | 422.24 (261.50, 681.79) | 393.97 (243.99, 636.13) | 183.79 (123.95, 272.53) | 204.94 (136.31, 308.12) |
| O1 Ogawa | 17.82 (10.41, 30.49) | 18.66 (10.90, 31.93) | 473.95 (292.57, 767.78) | 412.60 (254.70, 668.39) | 179.59 (115.49, 279.29) | 195.04 (123.49, 308.05) |
| O139 | 30.31 (19.09, 48.13) | 40.00 (25.19, 63.51) | 272.21 (185.21, 400.08) | 201.59 (137.16, 296.28) | 171.48 (123.76, 237.62) | 160.00 (114.15, 224.26) |
| Young children | (n = 29) | (n = 29) | (n = 29) | (n = 28) | (n = 28) | (n = 28) |
| O1 Inaba | 9.09 (5.88, 14.04) | 10.49 (6.79, 16.20) | 369.34 (215.10, 634.21) | 118.88 (68.57, 206.09) | 148.55 (87.98, 250.81) | 90.54 (53.63, 152.87) |
| O1 Ogawa | 10.24 (6.72, 15.62) | 9.76 (6.40, 14.89) | 360.62 (221.05, 588.31) | 152.27 (92.53, 250.57) | 181.08 (113.51, 288.88) | 148.55 (93.12, 236.98) |
| O139 | 33.84 (21.30, 53.76) | 13.97 (8.80, 22.20) | 457.99 (328.10, 639.30) | 185.62 (132.19, 260.64) | 220.74 (158.66, 307.12) | 124.91 (89.78, 173.79) |
GMTs are significantly different if their respective 95% confidence intervals are non-overlapping.
a
Geometric mean titres.