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. 2020 Jan 13;21(2):490. doi: 10.3390/ijms21020490

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anti-proliferative and radio-sensitizing effects of APR-246 in H3K27M DIPG cells. Proliferation assay with SF8628 pediatric diffuse intrinsic pontine glioma (DIPG) cell line harboring the histone H3.3 K27M mutation. The growth inhibitory and radiosensitizing effects of APR-246, by comparing the cell counts with 4 Gy dose (+) of radiation (crossed bars), versus without (−) radiation treatment (open bars). The cells were treated with the indicated concentrations of APR-246 for 6 h, then subjected to 4 Gy dose of radiation (or mock-treated). Ninety-six hours post-treatments, the cell counts were determined and plotted along the Y-axis. **** = p < 0.0001. ns = not statistically significant.