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. 2020 Jan 13;21(2):490. doi: 10.3390/ijms21020490

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Radio-sensitizing effects of APR-246 combined with GSK-J4 in clonogenic survival assays in H3K27M DIPG cells. Clonogenic survival assays with SF8628 pediatric DIPG cell line harboring the histone H3.3 K27M mutation. DIPG cells were pre-treated for 5 days with 0.5 µM concentration of GSK-J4 and APR-246 before plating and radiation treatments (0–10 Gy doses). Survival fractions were determined 2 weeks after plating. Curve fitting was performed using linear quadratic equation. Sensitizer enhancement rations (SERs) were calculated for the dose 4 Gy. Mean SERs from two independent experiments with 3 data points per experiment are shown followed by SER_4Gy = sensitizer enhancement ratio at 4 Gy radiation dose.